The notion of the Fast-Dissolving Drug Delivery System (FDTs) developed from the need to provide patients with a conventional means of taking their medication. FDTs are solid unit dosage forms that dissolve or disintegrate swiftly without the use of chewing or water. Nimesulide is a crystalline medication with low bioavailability due to its strong hydrophobicity and low water solubility. One such technology is spherical micropelletization, which provides maximum dissolution with improved wettability as well as uniform and spherical pellet size to guarantee smooth drug transit through the stomach. The goal of this research was to create an uncoated Nimesulide micropellets with improved bioavailability and micromeritic characteristics that may be utilised to construct rapid dissolving tablets. FDTs were created using the formulated Nimesulide micropellets. All formulations were subjected to general physical properties and in vitro dissolution tests. To investigate the efficacy of super disintegrants such as sodium starch glycolate and croscaramellose sodium, many combination ratios were created at various concentration levels. There were several tablet evaluation parameters used. In terms of in vitro dispersion time and drug release, tablets containing the above super disintegrants outperformed other formulations.

Key words: Nimesulide, micropellets, FDTs, Super disintegrants and Bioavailability.