Background: In the Indian setting, premenstrual syndrome (PMS) and its severe form, premenstrual dysphoric disorder (PMDD) are understudied. Objectives: This study aimed to examine the prevalence, predictors, and impact of PMS on women's functional status. Methodology: A cross-sectional survey was conducted through online mode among 750 women, aged 15 to 49 years, who had regular menstrual cycles. The Chi-square and Fisher's exact tests were used to examine the data. Results: 20.67% of individuals had moderate to severe PMS, and 8.93% experienced PMDD, which was found to interfere with family relationships in 64.5% of participants with moderate to severe PMS and 88% of participants with PMDD, respectively. Multivariate logistic regression revealed that the significant predictors included women who were aged 15 to 30 years, overweight, employed, had a family history of PMS, who consumed an excess of sweet food and rarely consumed fruits and vegetables, who had a sleep duration of 0-4 hours along with stressful lifestyle and who experienced emotional/ physical/ sexual abuse. Conclusion: PMS has a tremendous impact on women's daily lives, diminishing their productivity and lowering quality of life. The development of educational modules aids in providing accurate information, emotional, and medical assistance for women's menstrual health issues.

KEY WORDS- Premenstrual Dysphoric Disorder, Premenstrual Syndrome, Prevalence, Prognosticators, PSST.