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Comparative effectiveness of Topical Calcipotriol and Topical Betamethasone Valerate in Mild and Moderate Plaque Type Psoriasis. An Open-Labelled Comparative Study

. Sana Imran, Uzma Najam, Lubna Farooq, Urooj Zafar, Mohammad Sair and Muneeza Lodhi


Abstract

Background:  Plaque-type psoriasis is a chronic inflammatory dermatosis type condition.

Aim/ Purpose: To assess the beneficial effects of topical Calcipotriol (0.005%) ointment when applied to mild and moderate plaque-type psoriasis.

Material and Methods: 80 patients with plaque-type psoriasis were included in an open-label, comparative 90-day case study at Dermatology Department at Jinnah Postgraduate Medical Centre (JPMC), Karachi, These patients have divided into two groups: group A received topical Betamethasone valerate (0.1 percent) ointment and group B received topical Calcipotriol (0.005 percent) ointment, with 20 patients in each mild and moderate plaque-type psoriasis. The PASI score, adverse effects, and serum calcium level were used to measure improvement in plaque-type psoriasis patients.

Results: This open-label comparative study on plaque-type psoriasis was evaluated using the Psoriasis Area and Severity Index (PASI) scores. PASI scores improved in patients with mild and moderate plaque-type psoriasis who received topical Calcipotriol ointment and topical Betamethasone valerate ointment. Skin irritation was more common in group-B patients with mild to moderate plaque-type psoriasis who received topical Calcipotriol ointment, but burning sensations, rashes, and telangiectasia were more common in group-A patients with mild to moderate plaque-type psoriasis who received topical Betamethasone valerate ointment. There was no significant difference in serum calcium levels in both the groups that received topical Betamethasone valerate and topical Calcipotriol ointments at day 30, 60 and 90.

Conclusion: Calcipotriol had better results in mild and moderate plaque-type psoriasis than Betamethasone valerate when given topically, with lower PASI scores and fewer side effects.

Keywords: Plaque type psoriasis, Betamethasone valerate ointment, Calcipotriol ointment, Psoriasis Area Severity Index (PASI) score, serum calcium level.

 

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