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Pulmonary Dysfunction in Patients with Chronic Hepatitis C

. Uzma Najam, Nasima Iqbal, Anum Khan Kasi, Syed Fazal e karim Faisal, Sumaira Riffat and Ruqaya Nangrejo


The aim of current study was to find out the frequency of pulmonary dysfunction in patients of hepatitis C and the association of obstructive and restrictive lung disease with HCV. A cross-sectional study was conducted at the Medical ward of Jinnah postgraduate medical center Karachi. To classify on the basis of Child-Pugh scoring, few investigations of all patients were done including abdominal ultrasound, Prothrombin time (PT), activated partial thromboplastin time (APTT), bilirubin, serum albumin level, anti-HCV antibody and PCR for HCV RNA. To detect the lung function, pulmonary function test was performed by using spirometer. Data was entered on Statistical Package for Social Science (SPSS) version-20. Mean age of study participants was 51.7 ± 4.6. Out of total 150 participants, 58 patients were having restrictive pattern of pulmonary function test while 14 patients were having obstructive pattern of pulmonary function test on spirometry. According to Child-Pugh grading, as the grade increased there was progressive increase in frequency of restrictive lung disease. It can be concluded that chronic HCV has a strong significant association with the lung fibrosis as the disease presents a restrictive type of picture in pulmonary function test and the frequency of restrictive lung disease increase with the advancement of chronic liver disease

Keywords: Hepatitis C virus, Chronic liver disease, Restrictive lung disease, Fibrosis

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