Background:- Osteoarthritis (OA) the most common form of arthritis worldwide may be a painful and debilitating condition, most commonly seen in female population. Purpose of the study was to find the association between hyperuricemia and BMI in knee osteoarthritis patients.                                                            Methodology: This observational cross sectional study was carried out on 375 diagnosed patients of knee osteoarthritis with age >40 years. Participants were selected by non-probability convenient sampling from the District Head Quarter (DHQ) hospital, Gujranwala and Aziz Bhatti Shaheed Teaching hospital, Gujrat during May to September 2022. Patients of knee surgery and rheumatoid arthritis were excluded from study. After taking written consent, data were collected. All data were entered and analyzed using SPSS software version 24. Chi Square test, independent t- test, ANOVA, Post Hoc test (Tukey’s HSD Test) and Pearson’s Correlation Co-efficient were applied for statistical significance at 95% confidence interval.

Results: Out of total 375 diagnosed knee osteoarthritis patients, females were observed  256 (68.3%) whereas males were 119(31.7%) and fourth part, 101(26.9%) of selected participants were of age  61-70 years. Relation between body mass index (Kg/m²) and serum uric acid (mg/dl)  was found strong positively (r=0.552) statistically significant  with p-value <0.001 in patients with knee osteoarthritis.

Conclusions: Findings showed that the body mass index and serum uric acid are strong positively associated in patients with knee osteoarthritis. Females were observed more prone to knee osteoarthritis as compare to males.

Keywords: Knee osteoarthritis, serum uric acid, Body mass index, hyperuricemia, association