In livestock Transboundary pox viral disease known as Lumpy skin disease (LSD) is OIE notifiable. It is severely increasing and affecting the livestock economics.There hasn't been much research and reporting on the LSD virus's zoonotic potential. After initially appearing in Zambia, the virus spread to many parts of the world in around 90 years. In eastern, southern and southeastern countries the estimated impact of LSD is 1.45 billion due to direct losses and production. The same disease was observed for the first time in 2019, from countries such as Bangladesh, Nepal, China, India Pakistan and next year in 2020 it was reported in Bhutan, Srilanka, Bangladesh Southeast China and Vietnam. In 2021, LSD expanded to other countries such as Malaysia, Cambodia and Thailand.Typically, LSD-affected cattle have a nodular lesion or skin mass that covers their entire body. Occasionally, systemic symptoms are also present.The major and most frequent way of mechanical transmission is believed to be hematophagous arthropods; nevertheless, additional transmission routes connected to the illicit animal trade have contributed to the rise of LSD in nations that were previously available from it.The OIE recommends viral neutralization as the industry-standard gold test for serological diagnostics. The OIE recommends viral neutralization as the industry-standard gold test for serological diagnostics. Virus isolation and its sequencing requires in LSD free countries. It is possible to control LSD by applying rapid control measures for viral infection such as vaccination. Specific vaccines for the control of LSD are suitable for the protection of castles and buffalo as compared to other heterologous vaccines.Lack of a specific LSD policy at the time the disease first appeared, a high density of susceptible, unvaccinated populations, ignorance among farmers and veterinarians, and existing laws prohibiting the slaughter of cattle all contributed to favourable conditions for the disease's spread to numerous states in nations like India. Recently, whole world is affected by the COVID- 19 and now LSD is further affecting the economies of the countries. So it should be reviewed to save the economy of the developing countries in Southeast Asia.