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Association of Hepatorenal Syndrome with Liver Cirrhosis

. Khalid Mahmood, Nasima Iqbal, Faizah Mughal, Hafiz Syed Muhammad Osama Jafri, Ghazal Irfan and Sarah Azhar


Abstract

Hepatorenal syndrome is the complication of end stage liver disease in which renal shut down occur. There might be some geographical variations in the disease pattern of liver cirrhosis and the frequency of different complications. So the aim of the current study was to find out the frequency of hepatorenal syndrome among patients with liver cirrhosis in Lahore Pakistan. A descriptive cross-sectional study was conducted at the department of medicine, Azra Naheed Medical College, Lahore during January to September 2021. For confirmation of liver cirrhosis, laboratory findings including prothrombin time and serum albumin and ultrasound finding of parenchymal changes in the liver were noted. For diagnosing hepatiorenal syndrome, serum creatinine level, 24-hour urinary protein and detailed urinary examination were performed. Data was analyzed by using Statistical Package for Social Science (SPSS) version 20. The mean age of the study participants was 45 ± 7.1 with male predominance (65%). Out of total 163 patients of liver cirrhosis, about 11.6% patients were confirmed cases of hepatorenal syndrome. Liver cirrhosis was graded on the basis of Child-Pugh classification, 4 patients fall in Group A, among them only 1 patient was confirmed for hepatorenal syndrome. Group B consisted of 107 patients and 13 were having hepatorenal syndrome while 52 patients were in Group C, out of them 7 were labelled for hepatorenal syndrome. It can be concluded that the frequency of hepatorenal syndrome is 11.6% among patients of liver cirrhosis. Diagnosis of hepatorenal syndrome at early stage and early initiation of treatment can minimize the mortality rate due to hepatorenal syndrome.

Keywords: Hepatorenal syndrome, Cirrhosis, Child-Pugh classification

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