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Synthesis, silico and Antibacterial Activity Studies of 2-((substituted phenyl) amino)methyl)-5-ethyl-4-((5-(4-nitrophenyl)furfural-2-yl)methylene)amino)-2,4-dihydro-3H-1,2,4-triazole-3-thiones)) Hybrids

. Alphonsus DSouza, Gururaja.R and Agnes Sylvia Dsouza


Abstract

A series of 2-((substituted phenyl)amino)methyl)-5-ethyl-4-((5-(4-nitrophenyl)furfural-2-yl)methylene)amino)-2,4-dihydro-3H-1,2,4-triazole-3-thiones)) were synthesised and tested for antimicrobial activity. According to the findings, compounds with a fluorine substituent at the para position had a significant antibacterial effect against B.substilis and A.aerogenes. The structure of newly synthesised compounds was determined using spectral data. C=N stretching was observed in IR spectra at 1710 Cm-1 and NH stretching was observed at 1589 Cm-1, whereas these Chiral carbons appeared as a doublet in NMR spectra.

Keywords : Triazole, furfural and schiff’s bases

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