Objective: To evaluate the changes in HDL, triglycerides and VLDL levels related to the frequency of cigarettes smoked per day among young adults.

Place and Duration: The University of Sindh and Indus Medical College Research and Diagnostic Laboratory, Tando Muhammad Khan from 1^st January to 30^th June 2022

Study design: An analytical cross-sectional

Methodology: Volunteer students, who smoke cigarettes of both gender and do not take any drugs affecting their lipid profile were included in this study. All the participants meeting the selection criteria were recruited for the study after providing them with a volunteer information sheet, and consent was received. After aseptic measures, an intravenous fasting blood sample was drawn and sent to a laboratory for a lipid profile. The data was filled in self-structured proforma. A Lipid profile was determined.

Results: A total of (145) participants both male and female were randomly selected.  Out of (145), 64 (44.1%) were smokers and 81 (55.9%) were nonsmokers. Among the smokers, 50(45.5%) were males while only 14(40.0%) were females. The mean age of smokers (n=64) was 22 ± 3.45 years while the mean age of nonsmokers (n=81) was 23.6 ± 5.14 years. Lipid profile compared among the mild smokers, moderate smokers, heavy smokers and non-smokers by one-way ANOVA. Mean and SD of triglycerides (mg/dl), VLDL (mg/dl), LDL (mg/dl) and HDL (mg/dl) compared among heavy smokers, moderate smokers, mild smokers and non-smokers. (p- value<0.001), (p-value <0.001), (p- value=0.26) and (p-value<0.01) respectively. Conclusion: It has been concluded that decreases in HDL levels and increases in Triglyceride and VLDL levels are significantly associated with the number of cigarettes smoked per day in the young adults.

Keywords: cigarette smoked per day, healthy, lipid profile, young age