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Seroprevalence of TORCH in Aborted versus non-aborted Women

. Abdul Haseeb, Aamir Ali Khattak, Azam Hayat, Mujaddad ur Rehman, Syeda Asma Bano, Bilal Ahmed, Ibrar Khan, Aneela Rehman, Rizwan Ullah and Shafiq Barki


Abstract

This study sought to determine the prevalence of TORCH (Toxoplasma gondii, Rubella virus, Cytomegalovirus, and Herpes simplex virus) infection in pregnant women’s in Abbottabad, Pakistan. TORCH infections seriously complicate pregnancy in poor nations like Pakistan. These infections may spread from the mother to the foetus, increasing the risk of intrauterine foetal mortality and congenital abnormalities. The current study is to check for TORCH infection while pregnant. Compared to the preceding illness, the initial infection has a greater fatality rate. IgM and IgG antibodies can be used to prove primary infection since they signify primary or recurring infection.5000 samples that were brought to the Hamdard laboratory for routine testing were included in the current investigation. According to the company, the ELISA method was used to detect IgM and IgG. IgM and IgG antibodies can be found using this approach, which is sensitive and specific. According to the current study, pregnancy-related TORCH infections occur 16.28% of the time. Toxo is responsible for 16.1% of complete abortions, 23.3% of incomplete abortions, 21 % of missed abortions, and 10.8 threatened abortions. Rubella is also responsible for abortion in pregnant females. Rubella is responsible for 34.7% complete abortion, 38.5% incomplete abortion, 40.7% missed abortion and 45.9% threatened abortion. CMV is also a TORCH agent and is also responsible for abortion. CMV is responsible for 27.9% complete abortion, 25.2 % incomplete abortion, 14.4 % missed abortion and 35.1 % threaten abortion. HSV is playing a critical role in abortion. HSV is responsible for 21.1 % complete abortion, 12.8 % incomplete abortion, 23.6 % missed abortion and 8.1% threatened abortion. TORCH varies from sample to sample how frequently anti-Toxoplasma Rubella cytomegalovirus and anti-Herpes simplex virus IgM and IgG antibodies are present. This study shows that TORCH infections need careful attention since they can lead to major malformations and abnormalities in both children and pregnant women.

Keywords: TORCH, Toxo, Rubella, CMV, HSV, IgG, IgM.

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