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Evaluation of the diagnostic utility of thyroid profile and thyroid antibodies in detecting subclinical hypothyroidism as part of a routine workup for women with infertility

. 1Dr Hina Moazzam, 2Dr Sadia Rehman, 3Dr Sadia Abdul Majeed, 4Dr Huma Salahuddin, 5Dr Khushboo Arif and 6Wahiba Sheikh


Abstract

OBJECTIVE:

To evaluate the diagnostic utility of thyroid profile and thyroid antibodies in detecting subclinical hypothyroidism as part of a routine workup for women with infertility.

MATERIALS AND METHODS:

Prospective case-control investigation was done in physiology department in collaboration with the department of gynecology and obstetrics at the JPMC Karachi, BMSI. Ethical approval for the study was obtained from IRB JPMC Karachi. Duration of study was 1 year from Jan 2018 till Jan 2019. There were 88 participants in the sample, who were split into two groups. Infertile group (group A) and control group (group B). Non-probability purposive sampling was employed because each group's subjects were chosen based on specified standards. In the current investigation, all subjects who met the eligibility requirements were registered. Each subject who took part gave their written consent. Information obtained was held in strict confidence. Data was analyzed using IBM SPSS version 23.

RESULTS:

 Serum T3, T4, TSH, anti TPOAb, and TBG levels differed significantly between the two study groups. There was significant mean difference obtained for TSH and antiTPO antibodies between fertile and infertile samples with p-value less than 0.05.

 

 

 

CONCLUSIONS:

A trend towards subclinical hypothyroidism and the incidence of anti-thyroid antibodies was observed within females who had UE infertility, when their thyroid hormone profile was compared with fertile females. Anti TPO-Ab can be used as a screening tool as well as a marker for identification of the risk factors of infertility.

 

 

KEY WORDS:

Thyroid, Hypothyroidism , Infertility, Antibodies

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