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Effect of A. indica on the expression profiles of CNN3 and BDNF genes in epileptic rats

. Sudha Rani1, Prem Kumar 1, Pavithra Dasari 1, Swathi 1, Ramesh Kumar 1, Pabbathi Sri Krishna1, J. Mercy Evangilin2, Sanjeev Kumar1, A. Roja Rani1,*


Abstract

Epilepsy is considered as the one of the serious neurological diseases and it is characterized by abnormal, excessive neuronal activity in the brain, related with many neurobiological, cognitive and psychological signs were noticed [1]. Several chemical drugs such as benzodiazepines also known as Diazepam, barbiturates, GABA (gamma amino butyric acid) analog, succinimides, hydantoins, carbamazepine were used in the management of epilepsy disease [2]. Currently in market, new drugs include levetiracetam, topiramate, zonisamide, lacosamide, and stiripentol are available and it is safe [3]. More importantly, these drugs cause mental slowing, mental confusion, ataxia, anorexia, aggression, sleep disturbance and impaired concentration [3].

Many reporters are focusing on herbal remedies for safe medicine for epilepsy. In this regard, several plant-based medicines such as myrtus communis [5], melanthera scanden [4], abies webbiana Lindl [6], crocus sativus [7] and Dodonaea viscosa [8] have been proved to possess potent antiepilepsy property in experimental models of epilepsy. Like-wise, traditional system of medicine many parts of Acalypha indica has been used to treat varieties of ailments, and its part are scientifically proved that diverse biological activities such as antioxidant [9] anti-bacterial [10], wound healing [11]. Therefore, A. indica is one of the most common and potent plant-based medicine in the management of various ailments. Here, we considering the strong literature reports on antioxidant actions of A. indica, this study was undertaken to evaluate the antiepileptic activity of leaf extracts of A. indica.

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