Glomerulonephritis appears as an autoimmune reaction against patient’s own antigens or might occur secondary to antigen attacking endogenously or exogenously or any infectious agent or malignancy or any metabolic disorder. There is a global rise in glomerulonephritis among children with serious morbidity. The current study aimed to analyze the histopathological pattern of renal diseases on renal biopsy in pediatric patients of glomerulonephritis. A descriptive cross-sectional study was conducted from March 2016 to July 2022 at the pediatric ward of Peoples university of medical and health sciences, Nawabshah. Ultrasound, baseline investigations and liver function test was performed prior starting the procedure. International protocols were followed for biopsy procedure. Diagnosis of glomerulonephritis was carried out by using Haas grading system. Statistical Package for the Social Sciences (SPSS) version 20 was used to analyze the data. The mean age of the study participants was 9.2 ± 2.7 years with male predominance. Majority of patients were reported with pathology of focal segmental glomerulosclerosis (41.7%) followed by mesangial proliferative glomerulonephritis (20.5%) while very few of the patients were having pathological characteristics of diffuse proliferative glomerulonephritis (5%). Diffuse proliferative glomerulonephritis, minimal change disease and mesangial proliferative glomerulonephritis were more common in less than 5 years of age while focal segmental glomerulosclerosis, membranous nephropathy and membrano-proliferative glomerulonephritis were more common in 6 to 10 years of age and Lupus nephritis was only found with higher frequency in 11-14 years of age group. It can be concluded that the most common type of glomerulonephritis in pediatric age group is focal segmental glomerulosclerosis followed by mesangial proliferative glomerulonephritis.

Keywords: Nephropathy, Glomerulonephritis, Focal segmental glomerulosclerosis