The aim of the current study was to evaluate the hepatoprotective potential of Mimosa pudica leaves ethanolic extract against carbon tetrachloride (CCl4)-induced hepatic damage in Wistar rats. Mimosa pudica is famous for its anticancer alkaloid, mimosine, along with several valuable secondary metabolites like tannins, steroids, flavonoids, triterpenes, and glycosyl flavones along with pharmacological properties like antioxidant, antibacterial, antifungal, anti-inflammatory, hepatoprotective, antinociceptive, anticonvulsant, antidepressant, antidiarrheal, hypolipidemic activities, diuretic, antiparasitic, antimalarial, and hypoglycemic have been attributed to different parts of Mimosa pudica. Administration of carbon tetrachloride in rats significantly increased the levels of biochemical parameters of liver damage; bilirubin, cholesterol, alanine transaminase (ALT), alkaline phosphate, albumin, aspartate transaminase (AST), urea, and creatinine. Test animals were subjected to different concentrations of ethanolic extract of Mimosa pudica leaves (500mg/kg. 750mg/kg and 1000mg/kg) through oral administration.

Out of three doses, 500mg/kg showed better results in reducing the elevated levels of hepatic parameters and showed hepatocellular regeneration in CCl4-induced injured rats as compared with the CCl4 group alone. While higher doses (750mg/kg and 1000mg/kg) also showed significant results but less than 500mg/ml dose. Histopathological examination of the liver also indicated the protective effect of Mimosa pudica on injured liver tissues with improved architecture. The results of this study strongly suggest that mimosa pudica leaves extract has hepatoprotective and healing properties.

Keywords:

Hepatoprotective, Mimosa Pudica, Ethanoic Extract, CCl₄, Hepatotoxicity.