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FORMULATION & IN-VITRO EVALUATION OF SUSTAINED RELEASE TABLETS OF FROVATRIPTAN FOR THE TREATMENT OF MIGRAINE

. Srikrishna.T, A.Datta Charan, P.Venugopalaiah and Y.Ramesh


Abstract

Frovatriptan is a Triptan drug created by Vernalis for the treatment of headache migraines, specifically those related with period. Frovatriptan causes vasoconstriction of conduits and veins that supply blood to the head. Current research is about formulation and evaluation of frovatriptan Sustained Release tablets, F8 with 97.09% is the best formulation. Aim & Objective: Formulating Frovatriptan Sustained Release Tablets using various natural polymers. To study the effect of Drug polymer ratio or concentration of polymer on drug release. To study the effect of pre formulation studies on release of drug from tablet. To determine the kinetics and mechanism of drug release. Methodology: Analytical method development. Drug – Excipient compatibility studies. Preformulation parameters. Evaluation of   post compression parameters for prepared Tablets. In vitro drug release studies. Results & Discussion: The present study was aimed to developing Sustained Release tablets of Frovatriptan using various natural polymers. All the formulations were evaluated for physicochemical properties and In-vitro drug release studies. Conclusion: The aim of the present study was to develop Sustained Release Tablet formulation of Frovatriptan to maintain constant therapeutic levels of the drug for over 12 hrs. Xanthan gum, Guar gum and Karaya gum were employed as polymers. Frovatriptan dose was fixed as 2.5 mg. Total weight of the tablet was considered as 60 mg. Polymers were used in the concentration of 5 mg, 10 mg and 15 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation F8 (Karaya Gum-10mg) showed better and desired drug release pattern i.e.,97.09% in 12 hours.

 

Key Words: Frovatriptan, Prolonged Release Tablets, Migraine, Xanthan gum, Guar gum and Karaya gum.

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