Background:

Pakistan is in the top ten countries which are affected by chronic Hepatitis C virus infection. Elimination of infection is now a possibility due to advancements in medical science in the current era. Hepatitis C is occurring with multiple genotypes such as 1, 2, 3, 4, and 5. Genotype 3 is most common in Asian countries as compared to other genotypes. Direct-acting antiviral drugs had replaced liver transplantation in many cases and little knowledge is available regarding follow-up studies on these drugs.

Methods: A follow-up research was performed to evaluate 3 months of treatment outcome of some direct-acting antiviral drugs in 228 patients (177 patients of HCV genotype 3) ages 30-50 years using some relevant biological parameters.

Results: A total of 208 patients yielded a pooled SVR of more than 90% after twelve weeks of outcome of commonly used antiviral drug evaluation.

Conclusion: Commonly used antiviral drugs in Sialkot, Pakistan showed effectiveness in HCV patients having genotypes 1, 2, 3, 4 & 5.

Keywords: Hepatitis C virus, genotype 3, direct-acting antiviral drugs, liver function tests, renal function tests.