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SYNTHESIS OF CHITOSAN BASED NANOPARTICLES AND EFFICACY OF CORTICOSTEROIDS AND AMINOSALICYLATES FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE

. VENUGOPALAIAH.P, CH.PRAVEEN KUMAR & K.SAI RAJESH.


Abstract

ABSTRACT

Nanoparticles were considered as the revolutionized drug delivery system besides conventional drug delivery. Nanoparticles prepared with chitosan were found to be biodegradable and biocompatible with low toxicity which made chitosan as a valuable tool to manipulate the molecules and their structures. Chitosan nanoparticles can be delivered through parenteral and per-oral routes that offer a valuable tool for novel targeted drug delivery systems.Chronic inflammation of gastro intestinal tract due to inflammatory bowel disease was frequently occurred in young people. Anti-inflammatory drugs suppress the intestinal inflammatory burden with limited therapeutic efficacy by developing adverse drug reactions. Thus, the drugs have been targeted using novel drug delivery strategies for elevated therapeutic efficacy by diminishing adverse drug reactions. The efficacy of corticosteroids and aminosalicylates were explained using many randomized trials from 4 to 5 decades that continued till today. The review summarizes the structure and properties of chitosan, methods for production of chitosannanoparticles and efficacy of corticosteroids and aminosalicylates in the treatment of Inflammatory Bowel Disease.

Key Words:

Chitosan nanoparticles, Corticosteriods, Aminosalicylates, Ulcerative colitis, Crohn’s disease.

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