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PREFERENCE OF DOSAGE FORM AMONG PEOPLE OF KARACHI, PAKISTAN: A CROSS SECTIONAL STUDY

. Hira Akhtar, Khawaja Zafar Ahmed, Hafsa Batool, Maria Haider, Arhama , kashaf Baig, Warda Rafiq, Aqsa shaikh, Mariam sultani and Hidayat ullah


Abstract

As need of Dosage form is essential not only to treat diseases but also improves patient compliance the most widely available dosage forms are tablets and capsules. Patient have poor compliance to these Dosage forms as they faced problems of dysphagia and vomiting due to bitter taste. Geriatrics and Pediatric populations suffered a lot due to these problems however adult, geriatric and pediatrics prefer liquid Dosage form but one of the major drawback is its bad taste and dose inaccuracy. Pharmaceutical scientist to cope such problem formulated dispersible tablets and medicated lollipops to enhance all age’s patient’s comfort. The basic aim of this study is to highlight the problems faced by the general populations regarding dosage forms and to highlight the risk of dose ineffectiveness which occurs due to splitting, crushing, chewing or by taking the solid dosage forms such as tablets or capsules with milk or other beverages. A questionnaire based survey were prepared through Google form and link of the questionnaire were send to the people through Whatsapp. Data were analyzed by using SPSS version 25. A total of n= (123) participants respond the survey. Results showed that syrups are the most preferable dosage form for pediatrics and geriatrics however their bitter taste was intolerable, stability issues arises a lot in liquid dosage form as antibiotics are more prone to bacterial growth and hydrolysis. As injectables provides hundred percent bioavailability of the drug but patients feel pain at the site of injection and chances of side effects occurs which cannot be minimized as intravenous route is irreversible. However the popularity for dispersible tablets and medicated lollipops are increasing day by day as it increase patient compliance and provides pleasant feel in the mouth. This study also highlighted the importance of pharmacist to guide patients regarding dosage form intake without crushing, chewing and split the tablets, switching towards another dosage form and while taking the drug with milk or beverages. Although there are still the needs of dosage forms that increase patient comfort with minimal side effects and stability issues.

Index Terms- Dosage forms; Preference; Geriatrics; Pediatrics; Dysphagia

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