Objective: In this systemic review, we aimed to evaluate the combination of Anti- H. pylori treatment along with periodontal treatment to assess the rate of reinfection along with bacterial resistance against the drugs.

Materials and Methods: By using MeSH keywords such as “Helicobacter pylori and periodontal therapy”, “Helicobacter pylori and periodontitis”, “Helicobacter pylori and gingivitis”, “Helicobacter pylori and dental plaque”, and “Helicobacter pylori and oral cavity”. Databases such as PubMed, Google Scholar, and Web of Science were used to search for relevant studies which fell within the eligibility criteria of this study. The selected articles were then screened to ensure being in the English language. The relevancy of the selected articles was assessed as per the research question. The data of sample size, place of study, outcomes, and quality of assessment of the articles were extracted.

Results: In the initial search, a total of 801 articles were found, out of which 200 were initially eliminated. After further scrutinization, a total of 6 clinical trials were included. As per the results, reserves of Helicobacter pylori are present in the mouth. The combination of periodontal treatment with anti-H. pylori treatment resulted in a significant reduction in chances of reinfection with H. pylori along with the reduction in bacterial resistance to the drugs.

Conclusion: For doctors to diminish the chances of reinfection, complete eradication of H. pylori in gastric infection is of prime importance. To reduce the risk of reinfection, oral H. pylori can be eliminated by the use of mechanical instrumentation combined with treatment against helicobacter pylori for such patients.

Keywords: H. Pylori, Periodontal treatment, Gastric Treatment