Objective: COVID has not only taken a toll on the global healthcare system but also on the global economy. Vaccination is one of the most successful strategies used to curb COVID-19. This study was carried out to evaluate potentially associated cutaneous reactions due to COVID-19 vaccine.

Methodology: This was an observational, cross sectional, questionnaire-based study on dermatological adverse effects among people of Pakistan, by using a non-probability sampling technique.  The duration of the study was about six months, from August 1, 2022, to January 31, 2023. All 350 participants had received booster shots andsingle or double doses of any of the COVID-19 vaccines for instance AstraZeneca, Pfizer, Sinopharm, or Sinovac. The prevalence of dermatological adverse effects like pain, swelling, burning, rashes, lymphadenopathy following administration of 1st and 2nd doses of vaccination was also recorded Quantitative data was represented as mean and standard deviation, and qualitative data was reported as frequency and percentage.

Results:The study findings showed that out of 350participants,231(66.0%) were males and 119(34.0%)were females, with a mean age of 41.3±13.98 years, a mean weight of 66.92±15.18 kg, and a mean height of 5.32±0.73 inches. Fever 170(48.5%) was the most commonly observed side effect after the first dose of vaccination, followed by pain 139(39.7%), burning sensation 128(36.6%), swelling 123(35.1%), rashes 80(22.8%), lymphadenopathy 64(18.3%), and redness 52(14.9%) at the injection site. Similarly, after the second dose administration, the most often reported adverse effect was fever 122(34.9%), followed by pain in 118(33.7%) cases. The majority of people said they were satisfiedwith their immunization.

Conclusion:  This study concluded that fever, pain, and a burning sensation at the injection site, were observed to be the most common side effects of the COVID-19 vaccine following the first and second doses. Additionally, most of the adverse effects associated with COVID-19 vaccinations were mild to moderate and well-tolerated. In contrast, fever was the most common side effect observed after the first and second doses. 

Keywords: Side effects, COVID Vaccines, fever, pain, soreness, rashes