Background:

With the passage of time and advancements in the field of medicine, mesenchymal stem cells have played a significant role in the transplantation of kidneys.

Aims and objectives:

To assess the induction therapy of mesenchymal stem cells used for the transplantation of kidneys among the population of Karachi.

Methodology:

In the study, thirty patients were randomly selected in three groups from one of the public hospitals of Karachi, Pakistan from March 2021 to June 2022. Out of these ten patients from group A received a regular dosage, eight patients from group B received a low dosage of immunosuppressive drugs along with mesenchymal cells and seven patients from group C received anti-interleukin-2 receptor antibodies with regular dosages of immunosuppressive drugs.

Results:

The results of the study revealed that the group of patients treated with mesenchymal stem cells showed elevated eGFR values within the first month followed by surgery, and their renal function improved more quickly than that of the control group. Those patients who received a regular dosage of immunosuppressive drugs with mesenchymal stem cells had a mean difference of 5.2 mL/min per 1.73 m² (95% CI, 0.3-10.8; P=.03) and on the contrary, the group of patients who received a low dosage of immunosuppressive drugs with mesenchymal stem cells was 9 mL/min per 1.73 m² (95% CI, 3.9-15.8; P=.002).

Conclusions:

The study concluded that the use of mesenchymal cells among those patients who are going for kidney transplantation would reduce the chances of acute rejection along with low chances of infection with a better glomerular filtration rate within a year.

Keywords: Induction therapy, kidney, mesenchymal cells, transplantation

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