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DESIGN & DEVELOPMENT OF GLICLAZIDE FLOATING DRUG DELIVERY SYSTEM

. Srikrishna.T & S.Sucharitha


Abstract

The objective of this study is to formulate and evaluate alginate beads of Gliclazide using different proportions of sodium alginate and aloe vera gel powder for controlled/sustained drug release. Gliclazide is a second-generation sulfonyl urea used in the treatment of diabetes. The sulfonyl ureas drug class includes the effective oral antidiabetic medication Gliclazide, which is frequently used for the treatment of non-insulin dependent (Type II) diabetes mellitus. It is mainly absorbed from the stomach and is only moderately soluble in aqueous solutions. In order to improve the oral bioavailability of Gliclazide and to better control blood glucose levels to prevent hypoglycemia, which would improve clinical effectiveness and patient compliance, gastro retentive controlled release drug delivery systems are required. In the current study, floating microsphere tablets designed to increase bioavailability and achieve controlled release over 24 hours for once daily dosage. Alginate microspheres of Gliclazide were developed and tested as a model medication utilizing an ion cross-linking technique or ion gelation method with calcium chloride as the cross-linking agent. To deliver the medicament in the GIT in a controlled and sustained manner, as well as in combination with Aloe vera gel powder as a release retardant agent, the microspheres were formulated using sodium alginate both alone and in copolymer form. Particle size, angle of repose, yield, drug entrapment efficiency, degree of swelling, and invitro drug release tests were assessed for the prepared microspheres. Dissolution apparatus was used to assess the release rates.

Key words: Gliclazide, Alginate beads, Ion- cross linking method, Aloe vera gel powder, Sodium alginate, Diabetes mellitus.

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