Objective/Aim: To examine the effect of primary trabeculectomy in POAG with and without MMC 0.2%, we are comparing the IOP response to trabeculectomy with or without MMC 0.2%.

Methods: An experimental prospective study conducted at Chandka Medical College Hospital, Larkana, using the Department of Ophthalmology, was conducted between October 2015 and March 2016. There were 86 eyes of each gender, with ages ranging from 40 to 60 years. There were two groups of patients (02), which were equally divided. A total of 43 patients were involved in Group A, while 43 patients were involved in Group B as well. The test group was treated with MMC 0.2% alongside the trabeculectomy procedure as a primary procedure for three minutes, while the control group was treated with MMC 0.2% only. Both groups were followed for six months. Between October 2015 and March 2016, a study period was conducted.

Results: The total number of patients with POAG I studied was 86 eyes. In group A, trabeculectomy with MMC was carried out on all patients, while in group B, trabeculectomy without MMC was done on all patients. Approximately 25.39±2.42 mmHg of IOP was measured before surgery in Group-A, whereas 26.23±4.23 mmHg was measured in Group B. Among Group-A patients, the IOP was 13.20±3.05 mmHg on day 1, while it was 14.09±4.04 mmHg in Group-B patients. Among the 43 patients in Group A, 41 (95.3%) completed the treatment course. The treatment course was completed by 39 (90.7%) patients in Group B.  

Conclusion: In POAG, we found that trabeculectomy with MMC is better at controlling IOP after surgery than trabeculectomy without MMC. The first trabeculectomy procedure with MMC seems to work better than the first trabeculectomy procedure without MMC.

Keywords: Intraocular pressure, Primary Trabeculectomy, mitomycin, primary open angle glaucoma.