The study evaluated the qualitative analysis of phytochemical and antimicrobial activity of various solvent extracts from Carica papaya fruits and seeds. Phytochemical screening indicated the presence of saponnins, alkaloids, cardiacglycoside, tannins and anthraquinnon in the extracts. The analysis shows that the unripe fruit of Carica papaya can be ranked as carbohydrate rich fruit due to its high carbohydrate and starch contents. The chemical solvents used were ethanol, chloroform and benzene. Different solvent extracts of Carica papaya were tested against Gram positive and Gram negative bacterial strains by observing the zone of inhibition. The Gram positive bacterial used in the test were staphylococcus aureus and Bacillus cereus and the Gram negative bacterial were Escherichia coli, Pseudomonas aeruginosa. It was observed that ethanol, chloroform and benzene extracts of Carica papaya showed activity against bacteria, the chloroform extract of Carica papaya showed stronger activity against Escherichia coli and Pseudomonas aeruginosa. The ethanol extract showed stronger activity on Bacillus aurous and Escherichia coli. Chloroform extract in bacteria showed a varying degree of inhibition to the growth of tested organism. The fruit and seed of Carica papaya of the same plant contained the same constituent and could be used for the same purpose. The result confirmed the presence of antibacterial and antifungal activity of Carica papaya extract against various human pathogenic bacteria.