Introduction: As per regulatory bodies, National Institute of Health and World Health Organization, there will be drastic increase in neurodegenerative disorder affecting worldwide population in forth coming years. Hence an attempt been made to develop a potential role of phytochemicals in the management of Alzheimer’s disease.Methods:In the present study, different behavioural and biochemical models have been used. Results:Acacia catechu-Catechin (CTN) showed significant increase in Transferlatency and Escape Latency Time in behavioural models like Elevated Plus Maze and Morris Water Maze respectively.A dose dependent CTN (40, 20 & 10mg/kg) significant (P<0.01) inhibition of acetylcholinesterase (AchE) activity of whole brain was seen in scopolamine and aged mice, which were comparable to Standard Piracetam (400mg/kg). This potent neuroprotective characteristic of CTN was well supported by brain biogenic amines. In histopathology of hippocampus, the CTN treated mice were protected from the formation of pyknotic neurons and extent of cell death compared to Scopolamine group.In frontotemporal cortex of Sco + CTN (40 mg/kg) treated mice did not show internucleosomal DNA fragmentation and prominent laddering pattern.Whereas Scopolamine being a neurodegenerative inducing agent, also did not show anyinternucleosomal DNA fragmentation and prominent laddering pattern, even though   it damages the nerve cells as exhibited by the histopathology study, hence it reveals the novel information, that the scopolamine damages the nerve cell, but not to an extent of DNA damage.Conclusion:It is worthwhile to utilise an Acacia catechu-Catechin in the management of Neurodegenerative disorders of a type Alzheimer’s disease.

Key Words: Acacia catechu-Catechin,Anticholinesterase,Dopamine, Nor-adrenalin,Pyknotic neurons, DNA fragmentation.