Hypothyroidism is a condition where the thyroid gland doesn't produce enough thyroid hormone. It affects up to 5% of the population, with another 5% going undiagnosed. Studies show that hypothyroidism is linked to increased levels of triglycerides, LDL, and total cholesterol, and lower levels of HDL. This study aimed to evaluate the antioxidant and antihyperlipidemic potential of traditional medicinal herbs used in Pakistan to treat hypothyroidism. Ethanol extracts of Commiphora wightii, Moringa oleifera, and Withania somnifera were tested using total polyphenol, total flavonoid, and DPPH tests. The results showed that Moringa oleifera had the highest impact on DPPH radical scavenging activity, while all three extracts and a polyherbal formulation were effective antihyperlipidemic agents. These findings suggest that these traditional medicinal herbs may have therapeutic potential for treating hypothyroidism.

Keywords: Antioxidant, Antihyperlipidemic, Hypothyroidism.