Dexamethasone is the class of drugs that have been used extensively in a wide range of disease conditions and widely prescribed for their anti-inflammatory and immunosuppressive properties. Glucocorticoids have several side effects, being hyperglycemia one of the most common and representative. Hypertension and diabetes are common side effects of glucocorticoid treatment. Dexamethasone can cause elevation of patient blood sugar level. Steroids stimulate glucose production by the liver and inhibit peripheral glucose uptake, resulting in insulin resistance. Dexamethasone even after single dose administration has been shown to increase blood glucose. In the present case study a 56-year-old woman was hospitalized with the case of acute exacerbation of asthma with calcinosis cutis. Treatment regimen was planned accordingly including dexamethasone and clarithromycin. It was observed there are an elevation in blood glucose level upon administration Dexamethasone, it is known factor that dexamethasone capable to increase the blood sugar level and  concurrent use of clarithromycin may exaggerate the factor. Upon withdrawal of these two drugs the sugar level becomes normal.  Hence, it is advised that the judicious use of dexamethasone and its concurrent intractable drugs may be required to avoid the possible side effects of steroids.

Key words: Dexamethasone; Clarithromycin; Hyperglycemia.