Formulations having multiple crude drugs have been globally used according to literature records especially in Greek, ancient Egyptian, Chinese and Indian medical systems for miscellaneous therapeutic purposes. According to the World Health Organization (WHO), more than 80% of the world’s populace use herbal and traditional medications. Crude drugs used in Siddha, Ayurvedic, and Unani system of medicines, belong to any of the five sources of crude drugs i.e., animals, plants, marine, metals and minerals and microorganism. As crude drugs especially herbs have plenty of phytochemicals so use of bioactive compounds solely is not sufficient to attain desired therapeutic effects. Combinations of numerous crude drugs in a specific proportion sometimes exhibit better therapeutic effectiveness with minimal toxicity. This review chiefly focuses on therapeutic importance with clinical implication of Habb-e-Nareena. The Habb-e-Nareena is a polyherbal formulation that was mentioned by Hakeem Muhammad Shareef Dunyapuri and Hakeem Muhammad Yaseen Dunyapuri in their books to treat the women suffering from Gonorrhea, Leukoria, menstrual disturbances, recurrent miscarriage, infertility  and premature birth. The regional practices affirm that if the formulation is used after the completion of menstual cycle immediately, for almost 7 days then the women would certainly conceive within about one month or otherwise in next three months. Furthermore, the fetus must be a baby boy with XY gene combination. It is consisted of 6 crude drugs named as Mazu (whole), Bhang, Musk,  Mazu (aqueous extract), Kushta faulad and Feathers of peacock.