The aim of this study was to evaluate the pharmacological, phytochemical, and antioxidant potential of Rumex thyrsoides Desf. The ethanolic extract of the plant was used to examine its antipyretic, analgesic, and antispasmodic activities. The results showed that at a dose of 300mg/kg, the extract reduced the temperature to 93.66a±0.69°C in antipyretic activity and the amount of writhing’s to 7.6a±2.84 in analgesic activity, indicating (82.32 %) inhibition. In antispasmodic activity, the extract exhibited 44.50% inhibition, which was significantly lower than the standard drug atropine sulphate (94.15% inhibition). Qualitative investigation of the ethanolic extract showed the presence of proteins, carbohydrates, flavonoids, alkaloids, phenols, tannins, saponins, glycosides, and steroids. However, terpenoids were absent in the extract. The quantitative analysis of Rumex thyrsoides Desf revealed that the total phenol content was 3.58c±0.35, and the flavonoids content was 3.79c±0.36. Furthermore, the extract exhibited significant antioxidant activity at a concentration of 300mg/ml. These findings suggest that the plant contains effective chemical constituents that can be used to treat diseases effectively.

Key words: pharmacological, phytochemical, antipyretic, analgesic, Rumex thyrsoides Desf medicinal plants, qualitative, antioxidant.