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Identifying Risk Factors for The Development of Contrast-Induced Nephropathy in Patients Undergoing Coronary Angiography Developing Renal Insufficiency

. Dr. Jaghat Ram Dr. Muhammad Assa Baloch, Dr. Samiullah, Dr. Mashooque Ali Dasti , Dr. Shahbaz Ali Shaikh & Dr. Ghulam Mahdi Jamro*****


Objective/Aim: The objective of this research was to evaluate the potential reasons of CI-AKI among individuals who are receiving coronary angiography.

Background: The occurrence of acute renal failure after coronary angiography and percutaneous coronary intervention (PCI), known as contrast induced nephropathy, often leads to extended hospital stays and poorer outcomes. This investigation aimed to identify the multiple risk factors contributing to contrast induced nephropathy among patients receiving PCI.

Materials and Methods: The investigation was a prospective, descriptive analysis that took place at the Sheikh Mohammad Bin Zayed Al Nayhan Institute of Cardiology Quetta, focusing on 210 patients who underwent coronary angiography. The study employed a checklist to gather information, and Chi-square and regression analyses were employed to identify the risk factors associated with CI AKI.

Results: Regarding the gender of the patients, 141 (67.1%) were male and 69 (32.8%) were female. In terms of age, the majority of patients were in the 40-60 age group, accounting for 172 (81.9%) patients. The mean age of the patients was 61.6 ± 11.6 years. The use of nephrotoxic drugs was common among the patients, with 202 (96.1%) using NSAIDs, 138 (65.7%) using ACEIs, 34 (16.1%) using ARBs, and 30 (14.2%) using diuretics.

The results suggest that Diabetes has a strong positive association with the outcome (OR=16.158), while Type of coronary angiography and Volume of contrast media also appear to have significant positive associations with the outcome (OR=2.281 and OR=2.086, respectively).

Conclusion: Patients undergoing coronary angiography are considered to have the main risk factors for developing CI AKI.

Keywords: Coronary angiography, contrast-induced nephropathy, renal insufficiency

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