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Effects of dengue and malaria on CBC parameters and liver profile

. Asfa Ilyas, Umair Waqas, Mahnoor Fatima, Waqar Mehmood & Zouha Zafar


BACKGROUND: The study's goal is to determine how dengue and malaria infection affect CBC parameters and the liver profile. Malaria and dengue cases are rising yearly in the tropical and subtropical regions. If left untreated, it will only get worse and may even result in human death. Therefore, it is necessary to periodically examine how mosquito-borne illnesses like dengue and malaria affect CBC values, raise liver enzyme levels, and result in organ dysfunction in humans.


Methodology: Data was gathered in accordance with the guidelines established by the university of Lahore's ethics committee. The inclusion and exclusion criteria were used to choose the participants for this data. Without regard to age restrictions or gender discrimination, 140 samples were taken from individuals who had tested positive for dengue and malaria and whose CBC and liver profiles were abnormal. Blood was drawn into the appropriate vial tube, subjected to the appropriate testing, such as CBC on the Mindray BC600 and LFT on spectrometry, and the results were obtained.


Results: CBC and LFT were performed to check the effects of mosquito bite infection like malaria and dengue total 140 sample size were tested. when a patient contracts either malaria or dengue, malaria has a greater impact on HB levels than dengue. with dengue had lower TLC and PLT levels than those with malaria, which is mild. According to the severity of the infection, RBC damage, and the level of RBC in both infections is not significantly impacted. In contrast to dengue, malaria has a lower HCT%. Additionally, the patients' MCV, MCH, and MCHC levels reveal anemia and thalassemia. hepatic dysfunction in both infection malaria and dengue are associated with elevated levels of ALT, AST, and bilirubin.


Conclusion(s): We came to the conclusion that both dengue and malaria can result in serious haematological and hepatic alterations, with a high frequency of lymphopenia, anaemia, and thrombocytopenia in cases of malaria infection, and leukaemias in cases of dengue infection. Both infections can induce an increase of liver enzymes. When the aforementioned signs are present, the diagnosis of malaria and dengue should always be taken into consideration because the blood and liver profile changes are so distinctive.


Keywords: Dengue, Malaria, Hepatic dysfunction, HCT, TLC, PLT, HB, RBC

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