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EFFECT OF COVID-19 ON LIVER AND KIDNEY PROFILES
BACKGROUND: The wide family of single-stranded RNA viruses known as coronaviruses (CoVs) potentially invades both humans and animals and cause respiratory, gastrointestinal, liver, and cerebral disorders. These are the largest known RNA viruses. In an analysis of the clinical manifestations in COVID-19 patients, some researchers suggested that hepatocyte infestation with the immediate cytopathic effect of SARS-CoV-2 as well as interleukins storm, lack of oxygen conditions brought on by ARDS, and drug- Individuals having severe acute respiratory-CoV 2 experiences a broad spectrum of clinical indications, including acute, intermediate, chronic, quickly progressing, and symptomatic disease. The majority of SARS-CoV-2 victims remained healthy or mildly ill, and they died at rates that were less compared to severe acute respiratory-CoV as well as Middle East respiratory syndrome-CoV induced liver injury (DILI) may be held responsible for the pathological findings of COVID-19.
Methodology: Data was collected according to the rule and regulations set by the ethical committee of university of Lahore. The participants for this data were selected according to the inclusion and exclusion criteria. 551 blood samples were collected from patients suffering from COVID-19. A retrospective study design was used to conduct the research. As this was retrospective study so the data and clinical information about the demographic features of study population were collected through electronic medical record system from the pathology department of Aziz Bhatti Shaheed Teaching Hospital, Gujrat. The data and information which were collected included the information of patients regarding sex, age, chronic diseases (comorbidities) and other parameters such as alanine transaminase (ALT), aspartate aminotransferase (AST), enzymes present mostly in the liver, total bilirubin (TB), ALB also called serum albumin test and other parameters. data then was analyzed by SPSS.
Results: Out of 551 samples 511 give the positive results for urea, creatinine, total bilirubin, ALT, ALP, globulin. 510,506, 505 out of 551 samples give positive results for the AST, TP, and ALB respectively. The mean value of these tests is 55.3425, 1.4022, 0.6620, 74.4116, 183.2114, 3.0168, 67.386, 36.7354, and 3.960 respectively.
Conclusion(s): In the study there is now enough data to demonstrate the involvement of organs other than lungs in the Covid-19 patients. This study shows the effect of Covid-19 on the kidney and liver profiles in certain patients. Therefore the physicians and health staff should be aware of the clinical manifestations of Covid-19 so that a timely treatment is managed thereby eliminating the complications because of Covid-19. Several studies and investigations relating to the long-term impacts of Covid-19 on the liver and kidney profiles will definitely help in increasing our knowledge.
Keywords: Covid-19, Angiotensin-Converting Enzyme 2 (ACE2), Liver function test (LFT’s), Renal function test (RFT’s)