Dysfunction of left ventricle occurred even after improved surgical methods together with strict guidelines for the replacing mitral valves were followed. The dysfunction of LV (left ventricle) followed by MVR can be predicted through novelity of echocardiographic indices. It has been suggested that Left Ventricular echocardiographic GLS, which is obtained from strain imaging, is a novel measurement to represent dysfunction of latent LV in a more accurate way. A group of one hundred patients having severe MR (mitral regurgitation) were considered in this study, for mitral valve replacement (MVR). Strain imaging was done both at baseline and also after MVR during follow up.  To determine the threshold value of LV- echocardiographic GLS, for prognosis of left ventricle impairment after Mitral valve replacement, the Relative Operating Characteristics Curve had been sketched. For identification of the independent prognosticator of LV impairment persuing MVR, one dimensional and multi dimentional  regression investigation were conducted. Following MVR, patients with LVEF <50% exhibited lower LV-GLS from the set of data before any interventions are made (−19.9 vs. −17.7) compared to those with Left Ventricular Ejection Fraction ≥ 50%. Following three months of monitoring, patients with LVEF <50% exhibited markedly higher initial measurements of Left Ventricular End Systolic Dimension (35.36 mm versus 28.23 mm) and Left Ventricular End Diastolic Dimension (49.33 mm versus 45.10 mm) compared to those with Left Ventricular Ejection Fraction ≥50%. After MVR, patients exhibiting LV impairment were associated with a GLS threshold value of −19%, which had a sensitivity of 80.3% and a specificity of 75.7%. Echocardiographic GLS < -19% (OR = 25.7, CI:5.11-62.1, P=<0.001) was identified as an free prognosticator of Left Ventricular impairment following Mitral Valve Replacement in a multidimensional regression analysis. After MVR, echocardiographic GLS value below −19% was identified as a free prognosticator of impermanent LV impairment; another variable that confirmed the prognostication of Left Ventricular impairment after –Mitral Valve Replacement was an LVESD of ≥40 mm.

KeyWords:

MVR, GLS, LVEF, LVESD