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EVALUATION OF HELIANTHUS ANNUUS SEED EXTRACT FOR NOOTROPIC ACTIVITY

. Ms. Ramya D, Mrs. Zeena Fernandes NGSM Institute of Pharmaceutical Sciences, Department of Pharmacology, Deralakatte, Mangalore-574018


Abstract

Abstract

Objective

The present study was undertaken to carry out preliminary qualitative phytochemical screening and evaluate effect of ethanolic seed extract of Helianthus annuus on learning and memory of experimental animals.

Method

The phytochemical constituents were extracted by the maceration process using ethanol as solvent. The nootropic activity was assessed by Elevated plus maze, Y-maze, and Estimation of brain AchE activity after subsequent oral administration of the test extract for 7 days.

Result and Discussion

Preliminary qualitative phytochemical screening revealed the presence of phenols, alkaloids, flavonoids, triterpenoids, steroids, carbohydrates, and proteins. On pre-treatment with the test extract exhibited significant improvement in learning and memory activity in scopolamine-induced amnesic animals in a dose-dependent manner.

Conclusion

From the results obtained it can be concluded that ethanolic extract of Helianthus annuus seed has nootropic activity in a dose-dependent manner. However, there is a need for further investigation on the mechanism of action and result of the test extract on biochemical changes in the brain.

Keywords: Helianthus annuus, Cognitive disorders, Nootropics

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