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Synthesis, characterisation and Docking studies of 6-(4-fluorophenyl)-8-(5-(4-nitrophenyl)furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazepines

. Alphonsus D’Souza, Agnes D’Souza , Archana priyanka mendonca and Venuprasad K.D


Abstract

A series of 6-(4-fluorophenyl)-8-(5-(4-nitrophenyl)furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazepines were synthesised and screened these molecules for antimictobial activity and it was tested for cytotoxicity test and Docking scores for all the compounds are quite good against all the proteins. Among them, compounds 1 and 2 show best activities, having either the highest or second highest docking scores among the molecules. Compounds 1 and 2 can be potential leads as anti bacterials.

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