Sapindus trifoliatus Linn (Sapindaceae) is commonly known as reetha,which is used in Indian traditional medicine to treat various ailments.The present study is aimed for the invivo antinflammatory activity of ethanolic extract of stem bark of Sapindus trifoliatus by carrageen paw edema and cotton pellet granuloma induced inflammation models in wistar albino rats. Dried and powered stem barks were extracted using soxhlet extractor and screened for the various phytoconstituents present in the ethanolic extract of stem bark. Acute toxicity of the test extract was carried out by OECD guidelines 425.The test extract was administered orally with three different dose levels (100,200 and 400 mg/kg bodyweight) and anti-inflammatory activity potential was compared with Indomethacin as a standard drug. Preliminary phytoconstituents analysis showed the presence steroids, triterpenoids, saponins, glycosides.No mortality was observed for the test compound upto 2000mg/kg body weight.The stem bark extract showed significant dose-dependent reduction in paw edema when compared to the control at all time intervals,which was also comparable to that of produced by Indomethcin.The oral administration of test extract possessed significant level of anti-inflammatory activities possibly due to inhibition of prostaglandin production,supporting the evidence to the use of the plant stem bark as an anti-inflammatory agent.
Key words: Antiinflammatory, Sapindus trifoliatus, cotton granuloma method, pawedema, carrageenan