Coronavirus (COVID-19) is a communicable disease that is engendered by the SARS-CoV-2 virus which causes very common to severe symptoms and recovery does not require any specialized treatment. In this study, we have evaluated the effect of the different phytoconstituent present in the leaf of Azadirachta indica as a role in the management and treatment of COVID-19. Different constituents such as Limocinin, Rutin, Nimbinone, Nimbolin, Nimocin and Cycloartanols showed a satisfactory binding affinity towards SARS-CoV-2 protein molecular targets. These constituents were evaluated for various druggable properties like ADMET (Absorption, distribution, metabolism, excretion, and toxicity) profile along with its other physicochemical properties and medicinal chemistry that plays an important role in the draggability of these constituents.

 Keywords: Azadirachta indica, Coronavirus, SARS-CoV-2