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A perspective on the Pharmacology of Skeletal muscle relaxants

. Nimmy Chacko, Prerana Shetty, Ashwini Prabhu and Sharanya M


The word "Muscle relaxant" is used to refer to the two main categories of drugs comprising of neuromuscular blockers and spasmolytics. Skeletal muscle relaxants are used to treat spasticity of upper motor neuron syndromes and muscle pain or spasms in peripheral musculoskeletal disorders. There are different models through which skeletal muscle relaxant activity can be monitored, such as rota rod, inclined screen test, climbing test, chimney test, actophotometer and grip strength meter. The selection of skeletal muscle relaxant should therefore be based on individual medication and patient characteristics. An analysis summarizes the clinical conditions and screening methods associated with various spasticity and musculoskeletal disorders and lists medicinal plants containing active phytochemicals that possess skeletal muscle relaxant activity.


Key words: Skeletal muscle relaxant, Spasmolytic, Neuromuscular blockers, Screening, Medicinal plants

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