The selection of correct brand of drug by health professionals and patients is difficult day by bay, due to the availability of large number of generic brands in market. The aim of present study was to conduct various quality control tests for different marketed brands of nebivolol tablet available in India as per IP, in order to improve the safety, efficacy and to avoid health risk factors of the people. Four brands (A, B, C, and D ) of Nebivolol hydrochloride tablets (5 mg) marketed in India, were evaluated for various quality control tests including physical appearance, crown diameter, thickness, uniformity of weight, percentage drug content, hardness, friability, disintegration test, and dissolution test. The observed result shows that as hardness was increases the percent friability of the tablets was decreased notable in the in all formulations. Hence harder the tablets less will be the percent friability and vice versa. Dissolution study shows that more than 90 of drug releases from the brand A, B & C except brand D (86.5%). Pattern of drug release for the different brand was same. So result conclude that the prescription contain these brand can be interchangeable.

Keyword: Nebivolol Hydrochloride, quality control tests, dissolution profile