The present study evaluated the antiepileptic activity of Jatropha gossypiifolia Linn (Bellyache Bush) leaves using experimentally induced seizure models. Mice were subjected to maximum electroshock MES, N-methyl-D-aspartate NMDA 75 mg/kg, s.c, Pentylenetetrazole PTZ 70 mg/kg, i.p for anticonvulsant activity evaluation. Ethanolic extract of Jatropha gossypiifolia leaves were used at doses 100 mg/kg and 200 mg/kg.. Duration of flexion, extension, convulsion and stupor were measured. The mortality was evaluated by measuring % of protection. Both the doses of Jatropha gossypiifolia leaves and standard Phenytoin sodium protected 33.33%, 66.66% and 83.33% respectively and significantly P<0.001 reduced the number of animals convulsing and significantly delayed the all phases of seizures in MES-induced seizures. Similar protection was observed in PTZ-induced seizures and NMDA induced seizures in mice. Therefore the present study offered a scientific proof to the traditional use of Jatropha gossypiifolia Linn in epilepsy. The anti-epileptic activity of leaf extract may be due to enhancement of GABAergic neurotransmission and/or inhibition of calcium current. The significant anti-epileptic activity may be attributed to complex active constituents of the leaf extract.
KEYWORDS: Antiepileptic activity, N-methyl-D-aspartate, Pentylenetetrazole, Phenytoin sodium, Jatropha gossypiifolia.