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Fabrication and Evaluation of Fluvastatin Hydrogel Beads

. Wajeha Sajid and R.Venu Priya Department of Pharmaceutics, Anwarul Uloom College of Pharmacy, Mallepally 500001, Hyderabad , India.


The aim of the present work is to provide a therapeutic amount of Fluvastatin into the proper site in the body and also to achieve and maintain the desired concentration. Fluvastatin is slightly soluble in water. It is having half-life of 2hrs and low bioavailability. In the present study nine formulations were fabricated by using several polymers like HPMC K15M, Carbapol 934P and HPMC K4M in different proportion. The FTIR Spectra revealed that, there was no interaction between polymers and Fluvastatin. As the polymer ratio was increased, the mean particle size of Fluvastatin hydrogel beads was also increased. From the results it can be inferred that there was a proper distribution of Fluvastatin in the hydrogel beads and the deviation was within the acceptable limits. On the basis of released data and graphical analysis formulation F9 containing Carbapol 934P in higher proportion showed a good controlled release profile up to 12hrs with maximum entrapment efficiency because of high polymer concentration and follows zero order kinetics with super case II transport mechanism. Keywords: Fluvastatin, Hydrogel beads, Carbopol 934P, FTIR, HPMC K15M, HPMC K4M.

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