The main objective to establishment of biorelevant dissolution media for Abacavir Dispersible tablets is a useful technique for qualitative forecasting of the in vivo behavior of formulations. Dissolution tests that can predict the in vivo performance of Pharmaceutical drug products are usually called biorelevantdissolution tests. Biorelevant dissolution testing can be used to guide formulation development, to identify food effects onthe dissolution and bioavailability of orally formulation.To develop a biorelevant dissolution media for Abacavir Dispersible tablets for oral dosage forms, the physiological conditions in the gastrointestinal(GI) tract that can affect drug dissolution are taken into consideration according to the properties of the drug and dosageform. A variety of biorelevant methods in terms of media and hydrodynamics to simulate the contents and the conditionsof the GI tract are presented. The use of biorelevant media can have a great impacton the pharmacokinetic studies performed to optimizedosing conditions and product formulation. In addition,biorelevant dissolution testing could be used to assessbioequivalence of post-approval formulation changes in certain kinds of drugs.
Key words: Abacavir Dispersible tablets, Zeigen tablets 300 mg, biorelevant dissolution