The 1,3,4 oxadiazole nucleus is a biologically important scaffold with a wide range of biological activities. Because of their broad and potent activity, 1,3,4 oxadiazole and its derivatives have become important pharmacological scaffolds, particularly in the treatment of cancer disease. Several di-, tri-, aromatic, and heterocyclic substituted 1,3,4 oxadiazole derivatives with potent anticancer activity have been reported. These substituted 1,3,4 oxadiazoles had different mechanisms of action and were involved in the discovery and development of anticancer drugs. This review is intended to supplement previous reviews by reviewing the work reported on 1,3,4 oxadiazole derivatives from the year 2000 to the beginning of 2020.

Keywords: oxadiazole nucleus, scaffolds, Hemorrhage, anticancer, heterocyclic and discovery.