In this present work, we performed a facile solvothermal method for the active synthesis of chitosan (CS) coated copper oxide (CuO) nanoparticles. Further, conjugation of folic acid (FA) was done to generate FA-CS-coated CuO nanoparticles. The obtained final products were characterized to find the advancements in biological studies. The structural, functional, and optical analyses of the CS-CuO and FA-CS-coated CuO nanoparticles were characterized using X-ray diffraction spectroscopy (XRD), Fourier transform infrared spectroscopy (FTIR), UV-Vis spectroscopy. The thermal stability of synthesized nanoparticles was determined by thermogravimetric/differential thermal analyses (TGA/DTA). The crystallite size of nanoparticles was calculated to be 21.15 nm and 20.51 nm. Using Tauc’s plot the value of the bandgap energy was estimated to be 3.36 eV and 3.09 eV respectively. The explored results of the above-mentioned characterization studies revealed that the synthesized NPs could possess the adequate potential to execute further processes on targeted drug delivery.

Keywords: Copper oxide, chitosan, folic acid, nanoparticles