One of the significant classes of pesticides is that of the organophosphates (OPs). Starting improvements date back very nearly 2 centuries yet it was distinctly during the 1940s that OPs arrived at a noticeable status as insect poisons, a status that, yet declining, is as yet continuous. Operations are profoundly poisonous to nontarget species including people, the essential impacts being an intense cholinergic harmfulness and a postponed polyneuropathy. Several issues of current debate and investigation on the toxicology of OPs are discussed in this brief review. These include (1) Organophosphorus Pesticides Exposure, (2) Absorption, Metabolism, Biotransformation and Excretion of Organophosphorus Pesticides (Mechanism of Action of Organophosphorus pesticides: Acetylcholinesterase. A portion of these issues have been discussed and read up for quite a while, while others are more up to date, proposing that the investigation of the toxicology of OPs will stay a significant logical and general medical problem for a really long time in the future.

Key words: organophosphates, poisonous, Pesticides, Acetylcholinesterase