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Evaluation of neuroprotective effect of Ellagic acid against lead induced neurotoxicity

. Ananya Bhattacharjee , Venkatrao H Kulkarni and Prasanna V Habbu


Abstract

Aim of the study: The widespread use of lead causes rise in the amount of free lead in the different organs as well as in the environment. The nervous system is affected most for being major target of number of metals. Ellagic acid (EA), a natural polyphenolic compound, is having numerous potential medicinal properties. Materials and methods: The lead induced neurotoxicity was carried out in adult albino mice of both sex weighing 25-30 g. The doses of Ellagic acid were selected as 50mg/kg and 25mg/kg through oral route. After acclimatization, the animals were randomly divided into 4 groups of 8 animals and treated with ellagic acid high and low doses orally and simultaneously treated with lead acetate for three months. The extent to which EA treatment provides neuroprotective effect was measured by locomotor and cognitive function test, antioxidants like SOD, Catalase, MDH activity were measured in brain tissue homogenate. Other than that, estimation of MAO and acetyl cholinesterase were also performed. Remaining brains were subjected for histological examination. Results and conclusions: Observed results showed dose dependent beneficial effects for EA against lead acetate induced neurotoxicity and it was concluded that EA exhibited dose‑dependent protection against lead induced neurotoxicity.

 

Keywords: Ellagic acid, neurotoxicity, lead toxicity, heavy metal toxicity.

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