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GASTRO RETENTIVE DRUG DELIVERY SYSTEM: A NOVEL APPROACH TO ENHANCE GASTRIC RETENTION FOR CONTROL DRUG RELEASE

. Saikat Das and Ravindra Keshavrao Kamble


Abstract

Drugs that are easily absorbed from gastrointestinal tract (GIT) and have short half-lives are eliminated quickly from the systemic circulation. Frequent dosing of these drugs is required to achieve suitable therapeutic activity. To avoid this limitation, the development of oral controlled release formulations is an attempt to release the drug slowly into the gastrointestinal tract (GIT) and maintain an effective drug concentration in the systemic circulation for a long time. After oral administration, such a drug delivery would be retained in the stomach and release the drug in a controlled manner, so that the drug could be supplied continuously to its absorption sites in the gastrointestinal tract (GIT). Prolonged gastric residence increases duration of drug release, reduces drug waste, and improves drug solubility in gastric pH. We have reviewed various gastro retentive approaches designed and developed until now i.e. floating drug dosage systems (FDDS), swelling or expanding systems, mucoadhesive systems, high density system, Raft forming system, magnetic systems, super porous hydrogel system. Finally, advantages, disadvantages, potential drug candidates, mechanism, marketed preparation of gastro retentive drug delivery systems were discuss.

KEYWORDS: Gastro retentive drug delivery systems, Gastro retentive approaches, Marketed products

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