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Analytical methods for the determination of statin drugs used in Dyslipidemia and Hypercholesterolemia disease

. T.Nilotpal , J. Honey and B. Sudarshana, S. Bhupendra


Abstract

Statins are the first-choice drugs for the treatment of dyslipidemia and hypercholesterolemia disease. Statins are Hydroxymethyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors which is most widely prescribed drugs for the patients at risk of cardiovascular events. Cardiovascular disease (CVD) is ranked as the number one cause of mortality and a major cause of morbidity worldwide. All statins share a common mechanism of action and differ in their chemical structures, pharmacokinetic profiles and lipid-modifying efficacy. Abnormalities of serum lipids triglyceride, cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) are known risk factors for vascular disease. Some of the drugs used are rosuvastatin, atorvastatin, simvastatin and pravastatin. Clinical studies demonstrated that rosuvastatin is the most effective drug for reducing low-density lipoprotein cholesterol and triglycerides, followed by atorvastatin, simvastatin and pravastatin. A brief review of the analytical methods developed for the estimation of the above drugs was discussed in the present study.

 

Index Terms- statins, hypercholesterolemia, drugs, analytical methods

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