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DEVELOPMENT AND EVALUATION OF VALPROIC ACID LOADED NANOSTRUCTED LIPID CARRIER FOR ENHANCE BRAIN TARGETING

. A. KRISHNANAND, ABHISHEK DEY, S. KAMESH, S. VIGNESH, N. JAWAHAR AND V. SENTHIL


Abstract

Epilepsy is a neurological disorder with recurring as well as seizures. Nasal route: Since the BBB is impermeable to most of the drugs, delivering the drugs in therapeutically sufficient concentration into the brain is a tedious task. Many methods are being employed for brain targeting of the drugs. One of the most convenient routes among them is the nasal route of drug administration. This method proves efficient in delivering the drugs without causing damage to the BBB. There is a unique connection between the brain and the nasal route through which the drug can be delivered bypassing the BBB. Worldwide, there is a great influence of nanotechnology in pharmaceutical research groups from the initiation of the 20th century. Nanostructured Lipid Carrier (NLC) is the second generation of lipid nanoparticles having a structure like nanoemulsion. The unique advantages of NLC such as enhanced drug loading capacity and prevention of drug expulsion during storage make NLC is more favorable than Solid Lipid Nanoparticles (SLN). In addition to this, the usage of lipid carriers will increase the bioavailability and therapeutic effectiveness with low toxicity which can be acquired by changing the pharmacokinetics and biodistribution of the drugs. The prepared NLCs of Valproic acid had a drug release of 66.12% in 72 hours and permeations of 26.55% in 6 hours. The permeation study results indicate that the formulation is capable of getting absorbed through the nasal route.

Keywords: Valproic acid, nanotechnology, NLC, nasal spray.

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